CPT 45381 Colonoscopy with submucosal injection
RVU Snapshot
- Work RVU: 3.47
- PE RVU: 10.79
- MP RVU: 0.42
- Total RVU: 14.68
- Estimated Medicare payment: $490.33
- Global period: 0 days
- Assistant surgeon indicator: 1
- Co-surgeon indicator: 0
- Team surgeon indicator: 0
- Bilateral indicator: 0
- Multiple procedure indicator: 3
Gastroenterology Coding Note
Select CPT 45381 from the documented operative facts, approach, anatomic target, and separately supported work. Case Builder uses this same total-RVU Medicare estimate and applies modifier or MPPR adjustments only at the case level.
Related Phase A Codes
CPT 45384 - Colonoscopy with removal of lesion by hot biopsy/cautery CPT 45390 - Colonoscopy with removal of foreign body CPT 45391 - Colonoscopy with endoscopic ultrasound CPT 45398 - Colonoscopy with band ligationSource: CMS PFS RVU26C July 2026 non-QPP (PPRRVU2026_Jul_nonQPP.csv). Educational coding support only; confirm final billing against AMA CPT, CMS MPFS, NCCI, and payer policy.